Using Dual-TCR-Expressing T Cells Study of the Mechanism of TCR Antagonism
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منابع مشابه
Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities.
T cells expressing two different TCRs were generated by interbreeding 3A9 and AND CD4+ TCR transgenic mice specific for the hen egg lysozyme (HEL) peptide 48-62:I-Ak and moth cytochrome c (MCC) peptide 88-103:I-Ek peptide:MHC ligands, respectively. Peripheral T cells in the offspring express two TCR V beta-chains and respond to HEL and MCC. We observed minimal or no additive effects upon simult...
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